| Liga | Tiempo(Mexico City) | Redondo | Equipos | Resultados | Puntaje |
| CONCACAF Champions League | 02/15/22 21:00 | Round of 16 | Santos Laguna vs Montreal Impact | W | 1:0 |
| CONCACAF Champions League | 02/23/22 19:15 | Round of 16 | Montreal Impact vs Santos Laguna | L | 3:0 |
| Friendlies Clubs | 06/15/22 19:00 | Club Friendlies 3 | Guadalajara Chivas vs Santos Laguna | L | 3:1 |
| Friendlies Clubs | 06/18/22 19:00 | Club Friendlies 3 | Monterrey vs Santos Laguna | W | 0:1 |
| Liga MX | 07/03/22 18:05 | Apertura - 1 | Santos Laguna vs Monterrey | W | 4:3 |
| Liga MX | 07/08/22 20:05 | Apertura - 2 | Puebla vs Santos Laguna | L | 1:0 |
| Liga MX | 07/16/22 18:05 | Apertura - 3 | Santos Laguna vs Guadalajara Chivas | D | 1:1 |
| Liga MX | 07/23/22 16:00 | Apertura - 4 | Toluca vs Santos Laguna | L | 2:1 |
| Liga MX | 07/31/22 18:05 | Apertura - 6 | Santos Laguna vs Atlas | W | 1:0 |
| Liga MX | 08/06/22 20:05 | Apertura - 7 | Santos Laguna vs Cruz Azul | W | 4:0 |
| Liga MX | 08/14/22 18:05 | Apertura - 8 | Tigres UANL vs Santos Laguna | L | 2:0 |
| Liga MX | 08/18/22 18:05 | Apertura - 9 | Santos Laguna vs Leon | W | 2:1 |
| Liga MX | 08/21/22 11:00 | Apertura - 10 | U.N.A.M. - Pumas vs Santos Laguna | W | 1:5 |
| Liga MX | 08/25/22 20:05 | Apertura - 16 | Club Tijuana vs Santos Laguna | W | 0:2 |
| Liga MX | 08/28/22 18:05 | Apertura - 11 | Santos Laguna vs Atletico San Luis | W | 4:1 |
| Liga MX | 09/03/22 16:05 | Apertura - 12 | Pachuca vs Santos Laguna | L | 2:0 |
| Liga MX | 09/06/22 18:05 | Apertura - 13 | Santos Laguna vs Necaxa | W | 3:1 |
| Liga MX | 09/10/22 16:00 | Apertura - 14 | Club Queretaro vs Santos Laguna | D | 3:3 |
| Liga MX | 09/14/22 20:05 | Apertura - 5 | Club America vs Santos Laguna | D | 3:3 |
| Liga MX | 09/18/22 18:05 | Apertura - 15 | Santos Laguna vs FC Juarez | W | 2:0 |
| Liga MX | 10/02/22 17:05 | Apertura - 17 | Santos Laguna vs Mazatlán | W | 3:0 |
| Liga MX | 10/13/22 18:06 | Apertura - Quarter-finals | Toluca vs Santos Laguna | L | 4:3 |
| Liga MX | 10/16/22 18:06 | Apertura - Quarter-finals | Santos Laguna vs Toluca | L | 1:2 |
| Copa por México | 12/12/22 18:00 | Group Stage - 1 | Atlas vs Santos Laguna | D | 0:0 |
| Copa por México | 12/19/22 21:00 | Group Stage - 3 | Guadalajara Chivas vs Santos Laguna | L | 4:0 |
| Copa por México | 12/23/22 21:00 | Group Stage - 4 | Mazatlán vs Santos Laguna | W | 2:3 |
| Copa por México | 12/27/22 17:00 | Group Stage - 5 | Tigres UANL vs Santos Laguna | D | 1:1 |
| Liga MX | 01/08/23 19:00 | Clausura - 1 | Santos Laguna vs Tigres UANL | L | 0:3 |
| Liga MX | 01/14/23 21:10 | Clausura - 2 | Santos Laguna vs U.N.A.M. - Pumas | W | 3:0 |
| Liga MX | 01/20/23 21:00 | Clausura - 3 | Mazatlán vs Santos Laguna | W | 1:2 |
| Liga MX | 01/26/23 21:05 | Clausura - 4 | Atlas vs Santos Laguna | D | 2:2 |
| Liga MX | 02/04/23 21:05 | Clausura - 5 | Santos Laguna vs Club America | D | 2:2 |
| Liga MX | 02/11/23 19:05 | Clausura - 6 | FC Juarez vs Santos Laguna | L | 3:1 |
| Liga MX | 02/18/23 17:00 | Clausura - 8 | Atletico San Luis vs Santos Laguna | D | 1:1 |
| Liga MX | 02/23/23 20:05 | Clausura - 7 | Santos Laguna vs Toluca | L | 0:5 |
| Liga MX | 02/26/23 19:05 | Clausura - 9 | Santos Laguna vs Puebla | W | 3:2 |
| Liga MX | 03/04/23 21:05 | Clausura - 10 | Guadalajara Chivas vs Santos Laguna | L | 2:0 |
| Liga MX | 03/12/23 19:05 | Clausura - 11 | Santos Laguna vs Club Tijuana | W | 3:2 |
| Liga MX | 03/19/23 21:05 | Clausura - 12 | Leon vs Santos Laguna | L | 4:1 |
| Liga MX | 03/31/23 19:05 | Clausura - 13 | Necaxa vs Santos Laguna | D | 0:0 |
| Liga MX | 04/09/23 18:05 | Clausura - 14 | Santos Laguna vs Pachuca | L | 1:4 |
| Liga MX | 04/16/23 19:10 | Clausura - 15 | Monterrey vs Santos Laguna | W | 1:2 |
| Liga MX | 04/23/23 19:05 | Clausura - 16 | Santos Laguna vs Club Queretaro | L | 0:2 |
| Liga MX | 04/29/23 21:05 | Clausura - 17 | Cruz Azul vs Santos Laguna | L | 3:2 |
| Liga MX | 05/10/23 19:00 | Clausura - Quarter-finals | Santos Laguna vs Monterrey | D | 0:0 |
| Liga MX | 05/13/23 19:06 | Clausura - Quarter-finals | Monterrey vs Santos Laguna | L | 2:0 |
| Liga MX | 07/02/23 19:05 | Apertura - 1 | Santos Laguna vs Club Queretaro | L | 0:2 |
| Liga MX | 07/07/23 19:00 | Apertura - 2 | Puebla vs Santos Laguna | W | 2:3 |
| Liga MX | 07/13/23 19:05 | Apertura - 3 | Santos Laguna vs Atlas | D | 0:0 |
| Friendlies Clubs | 07/16/23 19:00 | Club Friendlies 3 | Santos Laguna vs Sporting Gijon | L | 1:2 |
| Leagues Cup | 07/29/23 17:30 | Group Stage - 3 | Santos Laguna vs Orlando City SC | L | 2:3 |
| Liga MX | 08/20/23 17:00 | Apertura - 4 | Cruz Azul vs Santos Laguna | D | 2:2 |
| Liga MX | 08/26/23 21:05 | Apertura - 6 | Santos Laguna vs Guadalajara Chivas | W | 2:1 |
| Liga MX | 08/30/23 21:00 | Apertura - 5 | Tigres UANL vs Santos Laguna | L | 3:2 |
| Liga MX | 09/02/23 19:00 | Apertura - 7 | Santos Laguna vs U.N.A.M. - Pumas | W | 2:1 |
